Coronavirus asymptomatic/immunity
Apr. 19th, 2020 11:32 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
izardI am following biorxive trying to find a publication about what makes asymptomatic covid carriers asymptomatic, or what makes people exposed to significal dose of the virus immune. So far most of articles are about treating the virus or managing patients in critical conditions. They are linked from my friends posts in lj, dw and facebook. Everyone is writing about CoVid now.
I have a first hand experience: my wife and me tested negative for antibodies. Why we tested? We did not have symptoms, but we were in contact with Covid19: 1.5 months ago my wife spent an hour in a small room talking with a colleague who was constantly coughing, and later he tested positive. Also in late March we spent 10 hours on a plane where half or the passengers were coughing.
We did not develop any symptoms - neither fever nor cough. There was still something.. I am a (lousy) freediver, and as swimming pools are closed, I can only train static apnea. In late March my usual apnoe timing quickly went down from ~2m20s to ~40s. That was just a few days, and now it is slowly recovering at ~1m40s.
So what happened when we were exposed to the virus but didn't get sick? Was it not enough virus particles we inhaled or swallowed, so that they did not end up on ACE2 receptors they could invade? Was a result of a job well done by IgA2s? Or we had high IgG specific for another coronavirus and it still worked? I am sure I am missing couple of other options here, and my main question is what are these options, and what are the ways to increase the probability of these things to work.
I have a first hand experience: my wife and me tested negative for antibodies. Why we tested? We did not have symptoms, but we were in contact with Covid19: 1.5 months ago my wife spent an hour in a small room talking with a colleague who was constantly coughing, and later he tested positive. Also in late March we spent 10 hours on a plane where half or the passengers were coughing.
We did not develop any symptoms - neither fever nor cough. There was still something.. I am a (lousy) freediver, and as swimming pools are closed, I can only train static apnea. In late March my usual apnoe timing quickly went down from ~2m20s to ~40s. That was just a few days, and now it is slowly recovering at ~1m40s.
So what happened when we were exposed to the virus but didn't get sick? Was it not enough virus particles we inhaled or swallowed, so that they did not end up on ACE2 receptors they could invade? Was a result of a job well done by IgA2s? Or we had high IgG specific for another coronavirus and it still worked? I am sure I am missing couple of other options here, and my main question is what are these options, and what are the ways to increase the probability of these things to work.
no subject
Date: 2020-04-20 09:27 am (UTC)no subject
Date: 2020-04-20 07:42 pm (UTC)асимптоматичная форма- это возбудитель присутствует в организме, размножается, выделяется, вызывает иммунный ответ (специфический и не специфический)- но симптоматика такая слабовыраженная, что ее почти нет (стертая).
при "асимптоматической" форме- возбудитель обнаруживается в образцах (анализах), так же, как и иммунный ответ на него. отсутствуют только "внешние" типичные, ярко выраженные симптомы.
есть еще "носительство" - когда обнаруживатеся только возбудитель, но не специфический иммунный ответ на него (если уже прошло достаточно времени для появления специфического иммунного ответа), когда инфекционный агент и и макроорганизм по какой-то причине "ужились". Тут есть варианты- инфекция может передаваться, или нет (зависит от ряда факторов)
так же есть вариант, когда "заразили" (то есть человек контактировал с возбудителем болезни), но не получилось болезни, тогда это просто "неудачная" попытка заражения (по разным причинам- тк это зависит, опять же от многих факторов, условий, и особенностей микроорганизма и макроорганизма).